Sunday, February 24, 2013

Stupid Celebrities Exclusive: Q & A at the Pre-Oscar Party Red Carpet

Stupid Celebrities Exclusive: Q & A at the Pre-Oscar Party Red Carpet

LMFAOWhile on the red carpet at the OK! Magazine’s Pre-Oscar Party, I got to snag a few of the celebs and grilled them a bit. LMFAO’s Stefan Kendal Gordy SC: What are you currently working on? SKG: I’m working on my own album right now. SC: Was there a movie that inspired you to do ...

Stupid Celebrities Exclusive: Q & A at the Pre-Oscar Party Red Carpet Stupid Celebrities Gossip Stupid Celebrities Gossip News

Source: http://stupidcelebrities.net/2013/02/stupid-celebrities-exclusive-q-a-at-pre-oscar-party/

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Video: Researchers develop protein 'passport' that help nanoparticles get past immune system

Video: Researchers develop protein 'passport' that help nanoparticles get past immune system

Friday, February 22, 2013

The body's immune system exists to identify and destroy foreign objects, whether they are bacteria, viruses, flecks of dirt or splinters. Unfortunately, nanoparticles designed to deliver drugs, and implanted devices like pacemakers or artificial joints, are just as foreign and subject to the same response.

Now, researchers at the University of Pennsylvania School of Engineering and Applied Science and Penn's Institute for Translational Medicine and Therapeutics have figured out a way to provide a "passport" for such therapeutic devices, enabling them to get past the body's security system.

The research was conducted by professor Dennis Discher, graduate students Pia Rodriguez, Takamasa Harada, David Christian and Richard K. Tsai and postdoctoral fellow Diego Pantano of the Molecular and Cell Biophysics Lab in Chemical and Biomolecular Engineering at Penn.

It was published in the journal Science.

"From your body's perspective," Rodriguez said, "an arrowhead a thousand years ago and a pacemaker today are treated the same ? as a foreign invader.

"We'd really like things like pacemakers, sutures and drug-delivery vehicles to not cause an inflammatory response from the innate immune system."

The innate immune system attacks foreign bodies in a general way. Unlike the learned response of the adaptive immune system, which includes the targeted antibodies that are formed after a vaccination, the innate immune system tries to destroy everything it doesn't recognize as being part of the body.

This response has many cellular components, including macrophages ? literally "big eaters" ? that find, engulf and destroy invaders. Proteins in blood serum work in tandem with macrophages; they adhere to objects in the blood stream and draw macrophages' attention. If the macrophage determines these proteins are stuck to a foreign invader, they will eat it or signal other macrophages to form a barrier around it.

Drug-delivery nanoparticles naturally trigger this response, so researchers' earlier attempts to circumvent it involved coating the particles with polymer "brushes." These brushes stick out from the nanoparticle and attempt to physically block various blood serum proteins from sticking to its surface.

However, these brushes only slow down the macrophage-signaling proteins, so Discher and colleagues tried a different approach: Convincing the macrophages that the nanoparticles were part of the body and shouldn't be cleared.

In 2008, Discher's group showed that the human protein CD47, found on almost all mammalian cell membranes, binds to a macrophage receptor known as SIRPa in humans. Like a patrolling border guard inspecting a passport, if a macrophage's SIRPa binds to a cell's CD47, it tells the macrophage that the cell isn't an invader and should be allowed to proceed on.


Penn's Dennis Discher explains how his lab designed a protein that acts a "passport" for the body's immune system. Nanoparticles equipped with this passport last longer in the bloodstream than equivalent particles without it.Credit: Kurtis Sensenig, University of Pennsylvania

"There may be other molecules that help quell the macrophage response," Discher said. "But human CD47 is clearly one that says, 'Don't eat me'."

Since the publication of that study, other researchers determined the combined structure of CD47 and SIRPa together. Using this information, Discher's group was able to computationally design the smallest sequence of amino acids that would act like CD47. This "minimal peptide" would have to fold and fit well enough into the receptor of SIRPa to serve as a valid passport.

After chemically synthesizing this minimal peptide, Discher's team attached it to conventional nanoparticles that could be used in a variety of experiments.

"Now, anyone can make the peptide and put it on whatever they want," Rodriguez said

The research team's experiments used a mouse model to demonstrate better imaging of tumors and as well as improved efficacy of an anti-cancer drug-delivery particle.

As this minimal peptide might one day be attached to a wide range of drug-delivery vehicles, the researchers also attached antibodies of the type that could be used in targeting cancer cells or other kinds of diseased tissue. Beyond a proof of concept for therapeutics, these antibodies also served to attract the macrophages' attention and ensure the minimal peptide's passport was being checked and approved.

"We're showing that the peptide actually does inhibit the macrophage's response," Discher said. "We force the interaction and then overwhelm it."

The test of this minimal peptide's efficacy was in mice that were genetically modified so their macophages had SIRPa receptors similar to human. The researchers injected two kinds of nanoparticles ? ones carrying the peptide passport and ones without ? and then measured how fast the mice's immune system cleared them.

"We used different fluorescent dyes on the two kinds of nanoparticles, so we could take blood samples every 10 minutes and measure how many particles of each kind were left using flow cytometry," Rodriguez said. "We injected the two particles in a 1-to-1 ratio and 20-30 minutes later, there were up to four times as many particles with the peptide left."

Even giving therapeutic nanoparticles an additional half-hour before they are eaten by macrophages could be a major boon for treatments. Such nanoparticles might need to make a few trips through the macrophage-heavy spleen and liver to find their targets, but they shouldn't stay in the body indefinitely. Other combinations of exterior proteins might be appropriate for more permanent devices, such as pacemaker leads, enabling them to hide from the immune system for longer periods of time.

While more research is necessary before such applications become a reality, reducing the peptide down to a sequence of only a few amino acids was a critical step. The relative simplicity of this passport molecule to be more easily synthesized makes it a more attractive component for future therapeutics.

"It can be made cleanly in a machine," Discher said, "and easily modified during synthesis in order to attach to all sorts of implanted and injected things, with the goal of fooling the body into accepting these things as 'self.'"

###

University of Pennsylvania: http://www.upenn.edu/pennnews

Thanks to University of Pennsylvania for this article.

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Source: http://www.labspaces.net/126976/Video__Researchers_develop_protein__passport__that_help_nanoparticles_get_past_immune_system

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Wednesday, February 20, 2013

T.J. Warren?s Monster Game Leads North Carolina State Past Florida State

Rob Kinnan-USA Today Sports

The importance of North Carolina State freshman T.J. Warren has been known for some time.

Long story short, when Warren is clicking on the offensive end, the Wolfpack are that much more dangerous, especially with March nearing its arrival.

On Tuesday night, Warren shone for a career-high 31 points. In addition, he grabbed 13 rebounds, which also marked a season-high. In turn, it was the first double-double of Warren?s young career.

As the disappointments continue to pile up for Florida State, the Wolfpack got exactly what they needed on Tuesday night: a convincing win. North Carolina State will find themselves jostling for position and seeding, not only for the upcoming ACC Tournament, but also in the NCAA Tournament.

A three-game losing skid earlier this month has quickly been countered by three consecutive wins, so head coach Mark Gottfried knows that his team has the capability of getting hot down the stretch. The Wolfpack are not currently ranked within the AP Top 25, but N.C. State certainly has the potential to make a run within the Big Dance, there is no doubt about that.

Moving forward, it?s clear that Warren?s importance and overall production will be counted upon more and more. It?s unlikely that Warren will have games like he did on Tuesday night, but that potential can certainly derail opponents. His contributions to the team will be just another worry for teams that N.C. State matches up with in the final weeks.

A true road test at North Carolina is on the docket for this weekend.

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Follow Paul Seaver on Twitter: @PaulSeaverRS

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Source: http://www.rantsports.com/ncaa-basketball/2013/02/19/t-j-warrens-monster-game-leads-north-carolina-state-past-florida-state/

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Tom Ford unveils clothing line in London catwalk debut

LONDON (Reuters) - American designer Tom Ford unveiled his womenswear line to the world on Monday in a lavish London Fashion Week debut that will help seal the city's credentials as a major international fashion hub.

Industry bloggers and buyers have flocked to London this season drawn by the big names on show, including Burberry, Erdem, Vivienne Westwood and Ford, who blended Inuit patterns, fur and pop-art designs in his cross-culture collection.

Once displayed behind closed doors for private clients and the editors of glossy fashion magazines, the collection's public showcasing coincides with the expansion of Ford's legion of stores in Europe and beyond, which will total 100 by the end of next year.

"We're in pretty much most major markets," Ford told Reuters after the show in the majestic rooms of historic Lancaster House, a short distance away from Buckingham Palace.

"We open our London store this fall ... and it's really the last of the major global capitals where we do not have a freestanding store," he said.

Even though it has produced some of fashion's biggest names, such as Alexander McQueen and Stella McCartney, London in the past has struggled to maintain its international profile on par with Paris, Milan and New York.

But with stars like singer Rihanna and fashion darling Ford heading this year's catwalk line-up along with well-established names like Westwood, London is rising to the challenge.

Justin Timberlake and Jessica Biel sat on the front row to watch a procession of sequined bomber jackets, cowhide skirts and sheer evening dresses with fur trims parade along the L-shaped runway, illuminated by roving spotlights.

"England does produce some of the most creative fashion designers in the world and often they do leave because they go to France or they go to Italy to work," Ford said, adding he would love to entice some big British names back to the British capital, where he lives and works.

"I would love to lure back my friend Stella McCartney, I would love to lure back other people, it would be great if McQueen showed here ... you know a lot of people who don't show here but live here and work here," he said.

The direct value of the British fashion industry to the UK's $2.5 trillion economy is 21 billion pounds ($32.6 billion), according to estimates from the British Fashion Council (BFC).

With buyers from 39 different countries attending, the BFC estimates orders of more than 100 million pounds are placed each season at London Fashion Week.

WHIMSICAL

Burberry sent a whimsical collection of its trademark trench coats down the runway embellished with heart motifs, animal prints and metallic detailing for Autumn/Winter 2013.

"The collection was really about the iconic Burberry colors, so black, white, camel and red, mixed with a little bit of gold," Chief Creative Officer Christopher Bailey told Reuters after the show.

Held in London's Hyde Park, models sported fitted dresses, chic pencil skirts, knitted jumpers and shiny golden belts.

"(Burberry) is smart, it's casual, it's cool, it's young. It's classic. It just caters for such a broad market," said British model and actress Rosie Huntington-Whiteley. "This is my favorite show to come and watch and I think Burberry always impresses everyone."

Opulent tones of burgundy, midnight blue and scarlet red featured across Christopher Kane's collection, along with revealing velvet dresses and feathered flower shapes sewn onto sheer tops and skirts.

The Scottish designer infused colorful camouflage prints into his collection, as well as floral appliques, feathers and fur.

Models donned boxy jackets with contrasting buckles, loosely cut trousers that hung off the hips and heavily embellished sheer silk dresses.

(Additional reporting by Dasha Afanasieva, Editing by Paul Casciato and Eric Beech)

Source: http://news.yahoo.com/tom-ford-unveils-clothing-line-london-catwalk-debut-010308703.html

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U.N. says has list of Syrian war crimes suspects

GENEVA (Reuters) - Syrians in "leadership positions" who may be responsible for war crimes have been identified, along with units accused of perpetrating them, United Nations investigators said on Monday.

Both government forces and armed rebels are committing war crimes, including killings and torture, spreading terror among civilians in a nearly two-year-old conflict, they said.

The investigators' latest report, covering the six months to mid-January, was based on 445 interviews conducted abroad with victims and witnesses, as they have not been allowed into Syria.

The independent team, led by Brazilian Paulo Pinheiro, called on the U.N. Security Council to "act urgently to ensure accountability" for grave violations, possibly by referring the violators to the International Criminal Court for prosecution.

"The ICC is the appropriate institution for the fight against impunity in Syria. As an established, broadly supported structure, it could immediately initiate investigations against authors of serious crimes in Syria," the 131-page report said.

It added: "Individuals may also bear criminal responsibility for perpetuating the crimes identified in the present report. Where possible, individuals in leadership positions who may be responsible were identified alongside those who physically carried out the acts."

Karen Konig AbuZayd, one of the four commissioners on the team of some two dozen experts, told Reuters: "We have information suggesting people who have given instructions and are responsible for government policy. People who are in the leadership of the military, for example."

"It is the first time we have mentioned the ICC directly. The Security Council needs to come together and decide whether or not to refer the case to the ICC. I am not optimistic."

But its third list of suspects, building on lists drawn up in the past year, remains secret. It will be entrusted to U.N. High Commissioner for Human Rights, Navi Pillay, upon expiry of its current mandate at the end of March, the report said.

Pillay, a former judge at the ICC, said on Saturday that Syrian President Bashar al-Assad should be probed for war crimes and called for immediate action by the international community, including possible military intervention.

"The evidence collected sits in the safe in the office of the High Commissioner against the day it might be referred to a court and evidence would be examined by a prosecutor," said a European diplomat.

The death toll in Syria is likely approaching 70,000 people, Pillay told the Security Council last week in a fresh appeal for it to refer Syria to the ICC, the Hague-based war crimes court.

Government forces have carried out shelling and aerial bombardment across Syria including Aleppo, Damascus, Deraa, Homs and Idlib, the independent U.N. investigators said, citing corroborating evidence gathered from satellite images.

"In some incidents, such as in the assault on Harak, indiscriminate shelling was followed by ground operations during which government forces perpetrated mass killing," it said, referring to a town in the southern province of Deraa where residents told them that 500 civilians were killed in August.

"SPREADING TERROR"

"Government forces and affiliated militias have committed extra-judicial executions, breaching international human rights law. This conduct also constitutes the war crime of murder. Where murder was committed as part of a widespread or systematic attack against a civilian population, with knowledge of that attack, it is a crime against humanity," the U.N. report said.

They have targeted queues at bakeries and funeral processions, in violence aimed at "spreading terror among the civilian population", it said.

"Syrian armed forces have implemented a strategy that uses shelling and sniper fire to kill, maim, wound and terrorize the civilian inhabitants of areas that have fallen under anti-government armed group control," the report said.

Government forces had used cluster bombs, it said, but it found no credible evidence of either side using chemical arms.

Rebel forces fighting to topple Assad in the protracted and increasingly sectarian conflict have committed war crimes include murder, torture, hostage-taking and using children under age 15 in hostilities, the U.N. report said.

"They continue to endanger the civilian population by positioning military objectives inside civilian areas," it said. Rebel snipers had caused "considerable civilian casualties".

"The violations and abuses committed by anti-government armed groups did not, however, reach the intensity and scale of those committed by government forces and affiliated militia."

Foreign fighters, many of them from Libya, Tunisia, Saudi Arabia, Lebanon, Iraq and Egypt, have radicalized the rebels and helped detonate deadly improvised explosive devices, it said.

The two other commissioners are former chief ICC prosecutor Carla del Ponte and Vitit Muntarbhorn of Thailand.

"It is an investigative mechanism and its evidence can be given to relevant judicial authorities when the time comes. In the interim, it is the one piece of U.N.-approved machinery shining a light on abuses," the European diplomat said.

Referring to del Ponte, who joined in September, the diplomat said: "She brings a harder-edged prosecutorial lens so when they are looking at the evidence she is very well placed to know what sort of evidence would assist a later judicial process."

(Reporting by Stephanie Nebehay; Editing by Alistair Lyon)

Source: http://news.yahoo.com/u-n-list-syria-war-crime-suspects-leadership-100842061.html

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Monday, February 18, 2013

Nostalgia Critic troops on through Dreamworks-uary with his review of Over the H...

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Breakthrough architecture for quantum computers proposed

Feb. 15, 2013 ? A team of researchers at the University of Waterloo's Institute for Quantum Computing has proposed a new computational model that may become the architecture for a scalable quantum computer.

In a paper to be published in the journal Science this week, the research team of IQC Associate Professor Andrew Childs, post-doctoral fellow David Gosset and PhD student Zak Webb proposes using multi-particle quantum walks for universal computation. In a multi-particle quantum walk, particles live on the vertices of a graph and can move between vertices joined by an edge. Furthermore, nearby particles can interact with each other.

Traditionally, a quantum algorithm is implemented on a register of qubits by actively manipulating the qubits according to a set of desired operations. In this new model, a desired quantum algorithm can be implemented by letting the qubits "quantum walk" on an appropriately chosen graph, without having to control the qubits. The process is analogous to a billiard-ball computer where classical logic gates are performed using collisions.

Many previous quantum-walk experiments have not been scalable. But this new model proposed by Childs and his team identifies the requirements to implement quantum walks so they have the potential for significant quantum speedup, paving the way for scalable future experiments. The model could be naturally realized in a variety of systems, including photons with interactions mediated by superconducting circuits.

Quantum walk-based computing is particularly promising because of its universality. "In principle we can cast any quantum algorithm into this model," says Childs. In future work, Childs and his team are interested in applying the model to develop new quantum algorithms and to study problems in quantum computational complexity.

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The above story is reprinted from materials provided by Institute for Quantum Computing.

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Journal Reference:

  1. A. M. Childs, D. Gosset, Z. Webb. Universal Computation by Multiparticle Quantum Walk. Science, 2013; 339 (6121): 791 DOI: 10.1126/science.1229957

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/matter_energy/physics/~3/xjO4rm2hZsM/130217084916.htm

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Friday, February 15, 2013

Are billboards driving us to distraction?

Feb. 14, 2013 ? There's a billboard up ahead, a roadside sign full of language and imagery. Next stop: the emotionally distracted zone.

One University of Alberta researcher has discovered that language used on billboards can provoke an emotional response that affects our driving abilities. And whether the words have a negative or positive connotation seems to determine whether the attention wanders or the foot gets heavier.

Lead study author Michelle Chan says that although plenty of literature exists on road rage, none of it deals with external emotional stimuli. Chan and her U of A co-author, psychology professor Anthony Singhal, devised an experiment using a driving simulator. Participants drove through one of three scenarios that exposed them to 20 billboards on the course; each billboard contained blocks of words that were positive, negative or neutral in nature. They were also tested for response by having to push a button on the steering wheel when they encountered a target word.

"Studies have shown that when subjects see an emotional stimulus as opposed to a neutral one, they're slower in making reaction time responses and they're slower when doing a visual search," said Chan. "I wanted to see whether the results would carry over in driving -- would we also find more distracted performance in driving? -- and we did see that."

Emotionally charged words affected the subjects' driving focus, something that may make driving in real conditions hazardous. Chan says that subjects who viewed the negative words decreased travelling speed when passing the signs and tended to drift and veer from their lane. Conversely, drivers viewing the words with positive connotations sped up when passing the signs -- a response the researchers said supported other research.

"There have been studies showing that when you're positively stimulated, your attention broadens, so you perform better when you're in a happy mood," said Chan. "In my results, we also saw that when we looked at the reaction-time data in response to target words, participants actually responded faster in the positive block than in the negative block."

Chan says a precedent already exists Down Under for dealing with this type of distraction, but some places may be harder to convince than others.

"In Australia they have really strict billboard criteria, but in the United States it's less so," she said. "When you're driving in Las Vegas, you'll see a bunch of profane billboards. There are also some really graphic anti-smoking billboards around."

Chan contends that emotional distraction while driving may come from anything from music to news to conversations, so it would be hard to legislate against those types of factors. Self-regulation on the images and language marketers use on billboards could be one way to reduce potential for emotionally related vehicular incidents.

Ultimately, she says, drivers need to take responsibility for their actions behind the wheel, even if it meets reducing the usual driving stimuli such as talking or listening to the radio.

"Any kind of distraction is risky when you're driving. But there would appear to be a larger risk when it comes to emotional stimuli."

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The above story is reprinted from materials provided by University of Alberta, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/ijSujPy23AQ/130214134024.htm

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Thursday, February 14, 2013

Jobless claims tumble in latest week

The number of people seeking unemployment benefits fell by 27,000 last week, an indication that hiring could improve.

The Labor Department says weekly applications dropped to a seasonally adjusted 341,000, the lowest level in three weeks. The four-week average, a less volatile measure, rose to 352,500, after reaching a five-year low two weeks ago.

The huge snowstorm that hit the Northeast this weekend seems to have had little impact on the data. The report covers the week ended Feb. 9, before the storm hit.

A department spokesman said Connecticut was unable to report data to the federal government earlier this week because state offices were closed after the storm. Illinois also didn't provide data, so both states' figures were estimated by the Labor Department.

Source: http://www.nbcnews.com/business/economywatch/jobless-claims-tumble-latest-week-1C8374530

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Wall Street rally stalls, S&P 500 skims November 2007 high

NEW YORK (Reuters) - Stocks were little changed on Wednesday amid investor caution after the S&P 500 index briefly hit its highest intraday level since November 2007.

The benchmark index got a boost from Comcast Corp , which said it will buy the rest of NBC Universal for $16.7 billion from General Electric Co .

Equities have been strong performers until recently, buoyed largely by healthy growth in corporate earnings, which helped the S&P 500 to rise 6.5 percent so far this year. The Dow industrials are about 1 percent away from an all-time intraday high, reached in October 2007.

Those gains have left the market vulnerable to a pullback as investors are likely to take profit amid a dearth of new catalysts. While analysts see an upward bias in stocks, recent daily moves have been small and trading volumes light with indexes at multi-year highs.

"I was expecting a 12-15 percent return on the S&P for the whole year of 2013, and we have done about half of that in just 5-6 weeks," said Jack De Gan, principal at Harbor Advisory in Portsmouth, New Hampshire.

"We will hit resistance, but the fundamentals and (microeconomic) picture are looking good, so if there is a correction, it's going to be a brief one."

The Dow Jones industrial average <.dji> was down 39.17 points, or 0.28 percent, at 13,979.53. The Standard & Poor's 500 Index <.spx> was up 0.80 points, or 0.05 percent, at 1,520.23. The Nasdaq Composite Index <.ixic> was up 7.01 points, or 0.22 percent, at 3,193.50.

Investors shrugged off the latest economic data, which showed that retail sales rose just 0.1 percent, as expected, in January as tax increases and higher gasoline prices restrained spending.

The S&P 500 was well above its 50-day moving average of 1,460.92, a sign the market could be overbought.

Comcast agreed late Tuesday to buy General Electric Co's remaining 49 percent stake in NBC Universal for $16.7 billion. Comcast jumped 4.4 percent to $40.70 as the S&P's top percentage gainer while Dow component GE was up 3.3 percent to $23.33.

Deere & Co reported earnings that beat expectations and raised its full-year profit outlook. After initially rallying in premarket trading, the stock fell 3 percent to $91.13.

According to the latest Thomson Reuters data, of the 353 companies in the S&P 500 that have reported results, 70.3 percent have exceeded analysts' expectations, above a 62 percent average since 1994 and 65 percent over the past four quarters.

Fourth-quarter earnings for S&P 500 companies are estimated to have risen 5.3 percent, according to the data, above a 1.9 percent forecast at the start of the earnings season.

Industrial and construction shares fell, though President Barack Obama, in his State of the Union address late Tuesday, called for $50 billion in spending to create jobs by rebuilding degraded roads and bridges.

The Dow Jones Home Construction index <.djushb> was off 0.5 percent.

(Editing by Kenneth Barry and Bernadette Baum)

Source: http://news.yahoo.com/stock-index-futures-point-slightly-higher-start-101356289--finance.html

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Wednesday, February 13, 2013

Origin Of Life In RNA? Study Suggests Genetic Molecules May Have Self-Assembled

By Robert F. Service

A pair of RNA-like molecules can spontaneously assemble into gene-length chains, chemists in the United States and Spain report. Billions of years ago, related molecules may have created a rudimentary form of genetic information that eventually led to the evolution of RNA and life itself, the researchers say. Although it's likely to be difficult, if not impossible, to prove whether similar proto-RNAs were present at the dawn of life, the researchers are working to see if the proto-RNAs can indeed faithfully encode information and evolve toward RNA.

Origin of life researchers have long thought that RNA, the molecular cousin of the DNA that encodes our genes, may have played a starring role in the initial evolution of life from a soup of organic molecules. RNA has a simpler structure than DNA and is a more adept chemical catalyst. So it would seem that RNA-based life might arise more readily than DNA-based life.

But there are problems with this so-called RNA World hypothesis. For starters, in water, the four chemical components of RNA?the nucleotides abbreviated A, G, C, and U?don't spontaneously assemble to create sizable molecules. So it remains a mystery how the first long gene-length chains of RNA could have taken shape in Earth's ancient oceans. This and other conundrums have led many to believe that RNA may itself be the product of early molecular evolution, and that proto-RNAs arose first and eventually gave way to RNA. "RNA is so perfect today that it has to be the product of evolution," says Nicholas Hud, a chemist at the Georgia Institute of Technology (Georgia Tech) in Atlanta.

rna lifeChemicals known as TAPAS and CA (left) assemble together forming rosettes (middle) that then stack into genelike chains (right).

Researchers have toyed with the idea of proto-RNA for decades and even come up with potential chemical candidates. One such set of proto-RNAs involves two chemicals called cyanuric acid (CA) and triaminopyrimidine (TAP). TAP comes from a family of compounds known as pyrimidines, as do the RNA bases C and U. CA, meanwhile, is a close pyrimidine relative. Previous research had shown that when CA and TAP were put in an organic solvent, groups of three CAs and three TAPs would spontaneously form ringlike structures called rosettes. These rosettes would then stack atop one another to form long chains.

Unfortunately, in water CA and TAP clump together in large ribbons and sheets and quickly fall out of solution, making it hard to conceive of how these proto-RNAs could have stored genetic information in the earliest stages of life.

Now, however, Hud and his colleagues at Georgia Tech and the Institute for Research in Biomedicine in Barcelona, Spain, have solved this solvent problem. The researchers gave TAP a short chemical tail, transforming it into a chemical they call TAPAS, as they reported on Friday in the Journal of the American Chemical Society. And that one change encourages it to assemble with CA to form rosettes in water. What is more, the rosettes stack atop one another, forming long genelike chains made up of as many as 18,000 individual TAPAS and CA components?quite a stack of small plates.

"The nice thing [about the current study] is this is a demonstration of self-assembly in water," says Ramanarayanan Krishnamurthy, an origin of life chemist at the Scripps Research Institute in San Diego, California. "That is a step in the right direction."

The next step, Hud says, will be to see whether this two-component assembly can be made to encode information like a primitive gene and to evolve toward the structure of RNA. If so, that still won't settle the debate as to whether CA and TAPAS gave life its start. But it will suggest one plausible chemical route to life's origin.


ScienceNOW, the daily online news service of the journal Science

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Source: http://www.huffingtonpost.com/2013/02/12/origin-of-life-rna_n_2670326.html

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Do we need 17+ hours of NBA All-Stars on TV? Nope

Television ? As a bonus, you can hear Charles Barkley talk about himself for an hour.

TNT is planning more than 17 hours of coverage related to the NBA All-Star Game, which seems like a lot for a game that doesn?t mean anything.

That?s not a slam at the NBA in particular. With the exception of Major League Baseball, there aren?t any all-star games that mean anything. (And MLB awarding the World Series home-field advantage to the league that wins its otherwise meaningless game remains a topic for debate.)

And the NBA All-Star Game might be the one contest that actually means more to the players than to the fans.

"The first one is always the most special," said ex-player/current TNT broadcaster Charles Barkley. "You take so many people with you. I took my mother, grandmother, my financial guy, my brothers."

"It was a dream come true," said TNT?s Steve Smith, who called it a "highlight" of his career.

It?s certainly a chance for the players to get some recognition, which they get so darn little of in the NBA. (That?s sarcasm, folks.) And it can be fun to watch if you aren?t a fan of defense or team play.

On Sunday, you?ve got the pregame (5 p.m.); the game (6 p.m.); and the postgame. But that?s just part of the story.

But there?s an argument to be made that the more interesting part of TNT?s TV plan won?t be All-Star Game itself. The rest of the schedule includes:

? The BBVA Rising Stars Challenge (Friday, 7 p.m.): Top young players on two squads chosen by Charles Barkley and Shaquille O?Neal play what amounts to, um, an all-star game.

There are no Jazz players on either roster, but there is one Utah tie. Karl Malone is scheduled to be a "guest analyst" on the halftime and postgame shows. Because a game like this really needs TV analysis.

story continues below

? The State Farm All-Star Saturday Night (6 p.m.) will feature the Sears Shooting Stars competition; the Taco Bell Skills Challenge; the Foot Locker and the Sprite Slam Dunk Contest ... because you can never have too many advertisers.

There is, at least, competition here. There?s an Eastern Conference vs. Western Conference angle, with points tallied throughout the evening and money raised for charity.

It was hard to argue with Barkley when he said, "Everybody loves the Slam Dunk contest." Just hope that team thing doesn?t ruin it.

The defending champion, Utah? Jeremy Evans, will return to compete.

? If you enjoy seeing people sit around and talk about basketball, you?ll want to check out "Open Court: All-Star" on Saturday at 5 p.m. Barkley, Miller, Steve Kerr, O?Neal, Kenny Smith, Steve Smith and Chris Webber will yack it up for an hour.

Because what an all-star game really needs is lots of pregam analysis.

? And if you enjoy Barkley talking about Barkley, don?t miss "Sir Charles at 50," an hour (Saturday, 9 p.m. ? time approximate) in which he reflects on his legacy as he approaches the half-century mark on Feb. 20.

I think I?ll probably skip that. And I?m a fan of his work on TV.

Next Page >

Copyright 2013 The Salt Lake Tribune. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://www.sltrib.com/sltrib/sports/55810182-77/game-star-barkley-nba.html.csp

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Tainz Holdings Limited thinks of establishing a new fund | Nicosia ...

Tainz Holdings Limited intends to make a proposal to Estonian-based investment companies to initiate a special residential real estate investment fund.

Since the first appearance on Estonian real estate market Tainz Holdings Limited has learned the situation on residential real estate market. Currently construction process of residential premises in Estonia is far from supplying a demand. Crisis has stricken hard and despite the fact that the agony of the market has finally stopped and Baltic economy crawls out of recession Estonia still experiences the shortage of residential real estate.

At the early days of investment activity on this market Tainz Holdings Limited has used to impalement direct capital placement. Now the company thinks of other form of investments. Investment funds are very popular and widely spread in this reason due to a number of benefits. Tainz Holdings Limited has used to participate in several investment funds on the territory of Cyprus which is a domestic market of the company, and Southern Europe.

Tainz Holdings

With the ambitious plans to take advantage of the most perspective opportunities in Estonia Tainz Holdings Limited plans to use the form of co-investments to implement expensive or complex projects. Moreover, the financial and advisory support of co-investors is a vital factor for foreign companies like Tainz Holdings Limited who seek to take leading positions on real estate market. Taking into account the present economic situation in the chosen region Tainz Holdings Limited intends to create a strong alliance of investment and construction companies to become a leader.

Tainz Holdings Limited runs several big investment projects on the territory of Estonia including the construction of residential complex for people with special needs. This is the first compound project of Tainz Holdings Limited carried out without any external support of other investment bodies. In future the company intends to expand the range of investment operations taking part in more complex and expensive projects.

Company contact information:

Courtney Williams
6, Maximos Michaelides Str, Maximos Plaza, Block 3, 5th Floor, Office 3504,
CY-3106, Limassol, Cyprus

Website: http://tainzhol.com

Source: http://nicosiamoneynews.com/2013/02/13/tainz-holdings-limited-thinks-of-establishing-a-new-fund/?utm_source=rss&utm_medium=rss&utm_campaign=tainz-holdings-limited-thinks-of-establishing-a-new-fund

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3 People Die in Chopper Crash While Filming Military-Themed Reality Show for Discovery Channel

LOS ANGELES (AP) ? Three people were killed Sunday in a pre-dawn helicopter crash in a rural area of northern Los Angeles County while filming for a new reality TV show for the Discovery Channel.

The copter crashed at about 3:40 a.m. at the popular filming location of Polsa Rosa Ranch in the city of Acton, Los Angeles County Fire dispatcher Robert Diaz said.

Helicopter Crash in California Kills 3 | Filming for Discovery Show

Source: KCAL

All three people aboard died, Diaz said. Their names weren?t immediately released.

The show, listed on a filming permit as an untitled military-theme TV program, had not yet been aired or announced by Discovery, channel spokeswoman Laurie Goldberg said.

?A production company was shooting a show for Discovery Channel when this tragic accident occurred,? the station said in a statement. ?We are all cooperating fully with authorities. Our thoughts and prayers go out to the families.?

The show?s production company, Eyeworks USA, best known for creating NBC?s ?The Biggest Loser,? also issued a statement expressing sympathies to the victims? families and saying they were cooperating with authorities.

The company had been approved to use a helicopter for a reality TV show shooting at the ranch from Saturday afternoon until Sunday morning, said Philip Sokoloski, a spokesman for FilmLA, which processes filming permits for location shootings in the Los Angeles region.

Records also showed that Crossbow Helicopters received approval to participate in filming from the Federal Aviation Administration.

?We wouldn?t have referenced helicopter activity if we didn?t already have pre-approval from the FAA,? Sokoloski said.

The cause and other circumstances surrounding the crash were still unknown, Federal Aviation Administration spokesman Allen Kenitzer said.

Television footage showed mangled wreckage in a rugged canyon area near Soledad Canyon Road.

Helicopter Crash in California Kills 3 | Filming for Discovery Show

Source: KCAL

According to its website, Polsa Rosa is a ?movie ranch? where film crews can utilize a variety of terrains as well as two airstrips. The ranch, according to the Internet Movie Database, was used in ?Windtalkers? and last year?s remake of ?Red Dawn.?

It was the site of another entertainment industry death in September, when a 48-year-old crew member died of an apparent heart attack while underwater in scuba gear on the set of the upcoming Johnny Depp film ?The Lone Ranger.?

Sunday?s wreck was also just 25 miles from a similar rural spot in Santa Clarita where actor Vic Morrow and two children were killed in another helicopter crash while filming the ?Twilight Zone? movie in 1982.

That crash brought changes in production restrictions and led to producer John Landis and four others being charged with involuntary manslaughter. All were acquitted.

?

Associated Press writer Andrew Dalton in Los Angeles contributed to this report. Tang reported from Phoenix.

Source: http://www.theblaze.com/stories/2013/02/11/3-people-die-in-chopper-crash-while-filming-military-themed-reality-show-for-discovery-channel/

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Quakertown Fire Co. BBQ Take Out 3/2 ? Alexandria Township, New ...

Posted by Alexandria Township on February 12, 2013

On March 2nd, the Quakertown Fire Company will be holding its first Chicken/Pork BBQ of the year. The menu choices are the quarter chicken which comes with their famous baked beans, salt potatos, and a drink. The pulled pork sandwich comes with the same sides and a drink. Both choices cost are $8.00 a piece. There are two types of soup being offered-Italian Wedding and Corn and Crab will be sold for $5.00 with a roll.

The BBQ is drive thru so you don?t even have to get out of your car. Delivery will also be available if you live in the fire district. Those wishing to pre-order should call the fire station at 908-735-5220. The Quakertown Fire Co. provides fire, rescue and medical services to central Hunterdon Cty. including the Townships of Alexandria, Franklin, and Union. The Station is located at 67 Quakertown Road in Pittstown. The event will start at 11 AM till all the food is gone!

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Source: http://alexandria-nj.us/2013/02/12/quakertown-fire-co-bbq-take-out-32/

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Friday, February 8, 2013

Catholic bishops reject Obama offer on contraceptive coverage

WASHINGTON (Reuters) - U.S. Roman Catholic bishops on Thursday rejected the Obama Administration's latest bid for compromise over a hotly disputed health policy that requires employees at religiously affiliated institutions to have access to insurance coverage for contraceptives.

Cardinal Timothy Dolan of New York, president of the U.S. Conference of Catholic Bishops, said his group would redouble efforts to reach an agreement on the contraceptives issue after more than a year of protest and scores of federal lawsuits from Catholics groups and other social conservatives.

But the cardinal, one of the most prominent voices in the American Catholic Church, said new federal rules proposed last week offer only "second-class status" to church-affiliated universities, hospitals and charities by failing to grant them the same full exemption afforded to houses of worship.

"These ministries are integral to our Church and worthy of the same exemption as our Catholic churches," Dolan said in a statement released by the bishops conference.

"The government would require all employees in our ?accommodated' ministries to have the illicit coverage ? they may not opt out, nor even opt out for their children," he said.

His remarks, coming on the heels of rejections from other opponents, including the Becket Fund for Religious Liberty, illustrate the scale of resistance facing one of the most controversial provisions of President Barack Obama's 2010 Patient Protection and Affordable Care Act.

The Catholic Health Association of the United States, the leading church-affiliated healthcare provider, declined to comment on Thursday, saying it was still seeking input from its 2,200 members, including 600 hospitals.

The contraceptives coverage is backed by liberal Catholic groups and women's rights activists.

The healthcare law already requires secular employers to cover all contraceptives and sterilization methods approved by the U.S. Food and Drug Administration, including the "morning after" pill.

But the administration is trying to reach an accommodation for religious nonprofit institutions whose employees would begin receiving coverage on August 1.

REDRESS IN COURT

Dolan criticized the administration for not addressing the issue of business owners who also oppose the policy on religious grounds.

"We cannot now abandon them to be forced to violate their morally well-informed consciences," he said. "We will continue to stand united with brother bishops, religious institutions, and individual citizens who seek redress in the courts for as long as this is necessary."

The proposed rules, issued on February 1 by the U.S. Department of Health and Human Services, would allow religiously affiliated employers to avoid paying for coverage. Private insurers would instead provide birth-control benefits through separate insurance policies.

Administration officials say insurers that provide group plans would be compensated by lower costs from fewer pregnancies and abortions.

Religiously affiliated institutions that provide their own health insurance for workers or students would be served by third-party administrators.

Third-party administrators would find an outside insurer to provide the contraceptives coverage. Those insurers' higher costs would then be compensated by lower user fees for participating in state-based healthcare exchanges, which are scheduled to begin operating on January 1, 2014.

The proposed regulations are open for public comment through April 8.

"We have been assured by the administration that we will not have to refer, pay for, or negotiate for the mandated coverage. We remain eager for the administration to fulfill that pledge," Dolan said.

"We welcome and will take seriously the administration's invitation to submit our concerns through formal comments, and we will do so in the hope that an acceptable solution can be found."

(Additional reporting by Ros Krasny; Editing by Jackie Frank and Philip Barbara)

(This story was corrected to fix spelling of cardinal's name to Dolan from Donlan throughout)

Source: http://news.yahoo.com/catholic-bishops-reject-obama-offer-contraceptive-coverage-000345295--finance.html

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No Boy Scout vote on gays until May

IRVING, Texas (AP) ? The Boy Scouts of America put off a decision Wednesday on whether to lift its ban on gay members and leaders, saying the question will be taken up at the organization's national meeting in May.

"After careful consideration and extensive dialogue within the Scouting family, along with comments from those outside the organization, the volunteer officers of the Boy Scouts of America's National Executive Board concluded that due to the complexity of this issue, the organization needs time for a more deliberate review of its membership policy," Deron Smith, the BSA director of public relations, said in a statement.

Smith said the organization's national executive board will prepare a resolution for the 1,400 voting members of the national council to consider. The annual meeting will take place in May, 2013, in Grapevine, Texas.

Walking to his car after the delay was announced, board member Jack Furst had very little to say.

"It's all good," Furst told The Associated Press before driving away.

The BSA announced last week it was considering allowing troops to decide whether to allow gay membership. That news has placed a spotlight on executive board meetings that began Monday in Irving, Texas, where scouting headquarters is located.

Smith said last week that the board could take a vote Wednesday or decide to discuss the policy, but that the organization would issue a statement either way. Otherwise, the board has remained silent, with reporters barred from the hotel where its meetings are taking place.

At nearby BSA headquarters, a handful of Scouts and leaders delivered petitions Monday in support of letting gay members join. The conservative group Texas Values, meanwhile, had organized a Wednesday morning prayer vigil urging the Scouts to keep their policy the same.

President Barack Obama, an opponent of the policy, and Texas Gov. Rick Perry, an Eagle Scout who supports it, both have weighed in.

"My attitude is that gays and lesbians should have access and opportunity the same way everybody else does in every institution and walk of life," said Obama, who as U.S. president is the honorary president of BSA, in a Sunday interview with CBS.

Perry, the author of the book "On My Honor: Why the American Values of the Boy Scouts Are Worth Fighting For," said in a speech Saturday that "to have popular culture impact 100 years of their standards is inappropriate."

The board faces several choices, none of which is likely to quell controversy. Standing pat would go against the public wishes of two high-profile board members ? Ernst & Young CEO James Turley and AT&T Inc. CEO Randall Stephenson ? who run companies with nondiscrimination policies and have said they would work from within to change the Scouts' policy.

Conservatives have warned of mass defections if Scouting allows gay membership to be determined by troops. Local and regional leaders, as well as the leadership of churches that sponsor troops, would be forced to consider their own policies. And policy opponents who delivered four boxes of signatures to BSA headquarters Monday said they wouldn't be satisfied by only a partial acceptance of gay scouts and leaders.

"We don't want to see Scouting gerrymandered into blue and red districts," said Brad Hankins, campaign director of Scouts for Equality.

Source: http://news.yahoo.com/boy-scouts-delay-decision-admitting-gays-153238089.html

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Thursday, February 7, 2013

How to Recover Data When Your Hard Drive Goes Belly Up

How to Recover Data When Your Hard Drive Goes Belly UpImagine this: you're busy working on your computer and need to access documents saved on your external hard drive. You connect it, get ready to find your data, and...nothing happens. Your hard drive isn't working. Uh oh. Before you panic, there are several things you can try on your own before calling in the pros.

Data loss can be due to a number of factors, but two are the most common. The first (and easiest to resolve) is software related. You've accidentally deleted an important folder and emptied the recycle bin, or gone and formatted the wrong drive by mistake. The second?and probably most common?cause of data loss is a fault with the hard drive itself. Given the complexity of modern drives it's no wonder that somewhere along the line something will go wrong. When the drive suffers from some form of failure there's often little that you can do yourself to get the data back?professional data recovery services are usually required. However, there are certain failures that you can attempt to resolve yourself.

Recover Your Data with Software

When dealing with a software data loss, the first and most important thing to keep in mind is not to work with the drive in question. Every second that the drive is connected to a running system is a second that you lose your chances at recovery. Your operating system is reading and writing to your drive constantly, whether you're actively doing something or not. Now that your system is seeing the deleted data as ?free space' it will happily overwrite this area?along with your chances of recovery.

  1. Shutdown the machine connected to the drive you've deleted data from. Now that your drive is ?safe' you can make a clone of the drive and attempt the recovery from the clone. There are a number of ways to clone the drive, some easier and quicker than others.
  2. Scan the clone with a few different recovery programs. There are numerous options here, both free and paid-for packages are available. Recuva is a good free option, while Zero Assumption Recovery works well if you want to splash out a few dollars.

How to Recover Data When Your Hard Drive Goes Belly Up

Pictured: The basic components of a hard drive with top cover off and PCB removed.

Recover Your Data with Hardware

Having covered the ?deleted data' section of data recovery is all good and well, but what happens if your drive is not even being detected by your machine? Or your machine can see the drive, but just hangs when you try to access it? What about if the drive is completely dead and won't even spin up? Let's briefly cover the main components of a drive, see which components can fail, and what symptoms each failure might exhibit.

PCB: This is the (often green) circuit board attached to the bottom of your drive. It houses the main controller (the equivalent of your computer's CPU) along with many other electronic controllers. This is the interface that turns your 0s and 1s from the platter into usable data that your computer can understand.

Platters: Your drive contains one or more thin, circular platters. These spin around at anywhere between 5,900rpm to 7,200rpm on consumer drives and are the media that actually store your data. Made of glass or some form of alloy and coated with a magnetic layer, they can store anything up to 4TB of data.

Head assembly: Data from your drives' platters is read by means of a series of read and write heads. While in operation, these heads are not actually in contact with the surface of the platters. In fact, they ?fly' nanometers above the surface of the disk, reading and writing data. Typically a drive will have 2 heads per platter, so a large capacity drive with 3 platters will be paired up with 6 heads, one for each side of each platter. If these heads fail physically or the drive is dropped or knocked over, the drive can experience a ?head crash' where the heads no longer fly over the platters, but instead make contact with the surface and destroy your data at a few thousand revolutions per minute.

Firmware: Your drive runs its own mini operating system in order to deal with all of the data and operations required to access it. Most of this firmware is stored on the platters. A small portion is stored on the PCB, which is required when the drive starts up. Firmware can go wrong, leading to inaccessibility of your data. Unfortunately hard drive firmware is not similar to your mobile phone or tablet?you cannot just update or reflash it. Each drive has its own unique modules and parameters and is highly complex in nature.

Now that we understand the basic components of a hard drive let's look at some common failures and symptoms you might experience, determine which component could be causing the problem, and see if we can tackle some of these problems DIY style.

If Your Drive Isn't Spinning Up At All

This is the one instance where you have a relatively good chance of resurrecting your drive if you're prepared to put in some time and effort. If the drive does absolutely nothing when you apply power to it (no noises at all), it is 99% a PCB problem. With older drives, you could sometimes find a matching PCB from another matching drive, swap it over, and voila. However, on new drives, technology and architecture have changed and each drive contains microcode unique to the drive it's attached to. Simply swapping the PCB with a matching, working equivalent has almost no chance of working and can be outright dangerous to your data.

There are two main causes of failure here, either a TVS diode (fuse) has shorted due to overvoltage, or a vital component on the PCB has failed. Hard drive PCBs often have two TVS diodes which act as fuses to protect your drive in the event of a power spike. There will most likely be two of these: one for the 5v and one for the 12v rail. If you accidentally plugged in the wrong power adapter to your external drive, or you experienced a power surge, a TVS diode might have sacrificed itself. If the shorted TVS diode is the only casualty and the rest of the PCB components are OK, then simply removing the shorted diode is enough to bring the drive back to life.

You can test this with a multimeter?if the diode reads zero ohms, or close to it, then it has indeed shortened. When shorted these diodes often have a noticeable burnt smell and might have visible burn damage. Note that when a TVS diode is removed the drive is no longer protected, so ensure that the power supply you connect to the drive is correct and healthy.

How to Recover Data When Your Hard Drive Goes Belly Up

Pictured: A PCB with the TVS diodes highlighted

If the TVS diodes don't smell burnt and show the correct digits when measuring them, then the problem is the PCB itself. A replacement PCB is required, but not just a straight swap. There is an 8 pin ROM chip on most PCBs that contains unique firmware info that is required to start up the drive. This needs to be moved from the old PCB to the new in order for the replacement to work. Some hard drives, especially Western Digitals, do not have this 8 pin chip?the firmware is stored in the main controller which is virtually impossible to move.

If you want to replace the PCB then you'll need to fine a matching replacement and have the ROM chip moved. There are many online providers that will sell you a matching PCB. Some of them even offer to move the ROM chip for you, saving you the hassle of soldering and possibly damaging the chip. If the PCB was the only damaged component and the drive's internals are OK, then after the replacement and ROM swap, your drive should be up and running again. Another PCB-related item to check are the head contacts. Sometimes they corrode with time, but are easily cleaned with a rubber eraser.

How to Recover Data When Your Hard Drive Goes Belly Up

Pictured: The contacts on a PCB can cause problems when they become tarnished like this.

If Your Drive Is Spinning Up and Making Clicking Noises

This is a serious failure and indicates a failed head or heads. It could also mean that your drive has suffered from platter damage if a head crash has occurred. Either way, this is a job for the pros. The drive will need to be opened in a clean room environment in a lab and a replacement head assembly fitted in order to try and recover your data. If your drive is clicking, it's best power it off and leave it in this state until you can send it to a professional recovery company. Powering it up in this state could degrade the disk further, to the extent that it's no longer recoverable.

How to Recover Data When Your Hard Drive Goes Belly Up

Pictured: A hard drive that experienced a head crash and made a deep scratch. This can render a drive unrecoverable.

If Your Drives Spins Ups and Is Detected by Your Computer, But Hangs When You Try to Access It

This usually means that the magnetic media is degraded. Basically, there are a large amount of bad sectors that the drive is trying to read, failing to do so, and hanging. This is a common problem that occurs over time and can be worked around, but only with professional data recovery equipment, more specifically a hard imager. If you look at the SMART values of the drive you'll notice and large amount of reallocated sectors to confirm your suspicions. If the data is important then send it off to the pros.

If you want to have a crack at it yourself (and risk making the problem worse or losing your data altogether) then you can try a software imager that can work around bad areas. Seeing that software commands ultimately goes through the BIOS, the effectiveness is limited. The best option if you want to go this route is a free Linux application called dd_rescue. It can skip bad areas and image in reverse.

If Your Drive Makes a Beeping Sound When You Power it Up

The beeping sounds you are hearing is the motor trying to spin the drive up and failing to do so. This is caused by one of two things, both serious mechanical failures. The most common is what's known as stiction. The heads of your drive park either in the center or on a ramp at the edge of the drive when not in use. Remember, the heads don't make contact with the data area of the platters, they fly just above. Sometimes, the heads can fail to park properly and the platters stop spinning with the heads still over the data area. Because of the extremely smooth surfaces of both the platters and heads, they literally stick to each other, hence the name stiction. The drive needs to be opened up in the lab, heads carefully removed and most likely replaced, definitely not a DIY job.

How to Recover Data When Your Hard Drive Goes Belly Up

Pictured: The head assembly with drive turned off and heads in the parked position. With stiction, they would be stuck somewhere on the platters.

The other cause could be seizure of the motor spindle. This is the spindle around which the platters rotate. It can become seized if the drive suffers a hard knock or drop. It's not a particularly common fault, except for Seagate drives as they have a particularly fragile spindle. There are two ways for this problem to be resolved, both of which require pro intervention. Either the spindle can be replaced or the platters are moved to a new hard drive casing along with heads, PCB, the works.

If Your Drive Sounds Normal but is Not Detected, or is Detected as the Wrong Capacity

This normally indicates a problem with some area of the firmware. Either it's not being read properly which could actually be head problem, or there is some corruption that needs to be resolved. A few years back there was a well-known bug with Seagate 7200.11 drives with firmware version SD15 known was the BSY bug. Googling this provide a wealth of info of the huge amount of failures were caused by this firmware glitch. There was a DIY solution for this particular problem, but with today's drives there is nothing that the end user can do but to send your drive in for professional help.

So, there are a few instances where you can attempt to recover your own data. If you've accidentally deleted your data then you might be in luck. If the drive is completely dead and won't even power up then you could go the DIY PCB route if you wish to tinker. Other than that, if your drive is making unusual noises or acting in a peculiar manner, you'll need to hand it over?together with some hard earned cash?to a data recovery professional. Remember, ANY attempts at data recovery are risky. If the data is important, take it directly to the professionals.


Nick Parsons is the Founder of SouthBit Data Recovery, leading data recovery service provider in South Africa. He founded SouthBit after receiving his honors degree in digital forensics. SouthBit Data Recovery rovides recovery services to all media including hard drives, SSD drives, and RAIDs. People can get more info on how their hard drive works by viewing their site at here.

Want to see your work on Lifehacker? Email Tessa.

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/nbiqZKlmKPI/diy-data-recovery-tricks-for-when-your-hard-drive-goes-belly-up

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Migrant workers at Sochi Olympic sites face abuses

In this Wednesday, Jan. 30, 2013 photo Eshkobil Ashurov visits a consultancy for migrant workers in Sochi run by Semyon Simonov, left. Like thousands of other workers in Sochi, Eshkobil Ashurov from the Central Asian nation of Tajikistan came to Russia several years ago in search of work to provide for this family back home. (AP Photo/ Igor Yakunin)

In this Wednesday, Jan. 30, 2013 photo Eshkobil Ashurov visits a consultancy for migrant workers in Sochi run by Semyon Simonov, left. Like thousands of other workers in Sochi, Eshkobil Ashurov from the Central Asian nation of Tajikistan came to Russia several years ago in search of work to provide for this family back home. (AP Photo/ Igor Yakunin)

In this photo taken on Monday, Feb. 4, 2013, a hotel under construction in Krasnaya Polyana, mountain Olympic cluster, 60 kilometers East from Sochi, Russia. One year from now Russia will be hosting the Winter Olympics at the Black Sea resort of Sochi, and these Games are being built with the hands of thousands migrant workers who are doing all the grunt work that Russians find too low-paid and physically demanding. In a hope to escape their impoverished countries and provide for their families, Central Asian migrants flock to Russia to live in crowded quarters and work long hours. (AP Photo/Dmitry Lovetsky)

In this photo taken on Monday, Feb. 4, 2013, hotels are under construction in Krasnaya Polyana, mountain Olympic cluster, 60 kilometers East from Sochi, Russia. One year from now Russia will be hosting the Winter Olympics at the Black Sea resort of Sochi, and these Games are being built with the hands of thousands migrant workers who are doing all the grunt work that Russians find too low-paid and physically demanding. In a hope to escape their impoverished countries and provide for their families, Central Asian migrants flock to Russia to live in crowded quarters and work long hours. (AP Photo/Dmitry Lovetsky)

In this Thursday, Jan. 31, 2013 photo Sohi's Mayor Anatoly Pakhomov poses with count-down clock in Sochi. One year from now Russia will be hosting the Winter Olympics at the Black Sea resort of Sochi, and these Games are being built with the hands of thousands migrant workers who are doing all the grunt work that Russians find too low-paid and physically demanding. In a hope to escape their impoverished countries and provide for their families, Central Asian migrants flock to Russia to live in crowded quarters and work long hours. (AP photo/Igor Yakunin)

In this photo taken on Monday, Feb. 4, 2013, a hotel under construction in Krasnaya Polyana, mountain Olympic cluster, 60 kilometers East from Sochi, Russia. One year from now Russia will be hosting the Winter Olympics at the Black Sea resort of Sochi, and these Games are being built with the hands of thousands migrant workers who are doing all the grunt work that Russians find too low-paid and physically demanding. In a hope to escape their impoverished countries and provide for their families, Central Asian migrants flock to Russia to live in crowded quarters and work long hours. (AP Photo/Dmitry Lovetsky)

(AP) ? One year ahead of the Winter Olympics in Sochi, the roads in the Black Sea resort and its surrounding mountains are lined with migrants from Central Asia doing the grunt work that Russians find too low-paid and physically demanding.

Tens of thousands of migrant workers from Uzbekistan, Tajikistan and Kyrgyzstan are a key element in Russia's intense drive to build facilities for the 2014 Sochi Games. The event is viewed as the country's biggest construction project and a matter of national pride ? for President Vladimir Putin, in particular.

But many migrants, whose pay typically provides for their entire families back home, complain that Russian contractors are cheating them and withholding their wages. Most of the foreign laborers speak poor Russian and many are afraid to assert their rights.

Human Rights Watch on Wednesday released a report drawing a vivid picture of the routine abuse faced by Sochi migrant workers: underpayment, withheld wages and the absence of employment contracts. The report came out a day before Putin and Olympic officials mark the one-year countdown to the games with a spectacular ice show.

For Eshkobil Ashurov of Tajikistan, working in Sochi has been a boon and a bane. The 27-year-old steel-fitter has been able to send money home to his wife, children, parents and sisters in his impoverished homeland ? but that's only when his employers actually pay him.

In December, he said, he walked off his previous job after going 40 days without pay. He said 40 of the 100 men in his work group also weren't paid and most of them left Sochi.

Ashurov found another construction job in the mountain area where the outdoor Olympic competitions will be held, but it's still a difficult life. He typically works 10 hours a day, seven days a week and earns about 30,000 rubles ($1,000 a month). He sends 27,000 rubles of that home, leaving him little to live on besides his employer-provided accommodation and food.

"We're here to work," he said in an interview. "You get back, spend some time at home and go back here to work."

Ashurov's situation is common, according to Semyon Simonov, who runs a two-man advocacy group for migrants in Sochi that provides free legal help. But it's hard to tell how many workers truly are affected.

Federal Migration Service chief Konstantin Romodanovsky recently said that out of 74,000 people involved in construction in Sochi, only 16,000 are foreigners.

But the actual figure of foreign laborers in Sochi is likely much higher. According to Simonov, who contrasted official statistics on work permits with data on foreigners registered in the area, about 50,000 people may be working in Sochi without work permits.

Simonov and Human Rights Watch list the withholding of wages, the failure to provide employment contracts and excessive working hours as the most common rights violations that migrants in Sochi face.

In the HRW report, researcher Jane Buchanan said millions will be watching the 2014 Games unaware that "many migrants toiled in exploitative, abusive conditions to build these shimmering facades and luxurious interiors." The rights group called on the International Olympic Committee to set up a working group to monitor and prevent the mistreatment of workers.

Olympstroi, the Russian state company responsible for building the Olympic venues, said in a statement it has carried out more than 1,300 work inspections since 2011 but has identified only five cases of "wage irregularities."

The IOC reiterated its "long-standing commitment" to follow up cases of mistreatment or abuse and said it has been in contact with Human Rights Watch. In a statement, the IOC said it brought the issue of migrant workers to the attention of the Sochi organizing committee and had received information on the topic from Olympstroi.

"We can confirm that Olympstroi has carried out more than 1,300 work inspections since 2011 and that a small number of cases regarding wage irregularities were identified and dealt with satisfactorily," the IOC said. "'We would continue to urge HRW to furnish us with the details of cases that allow us to deal with them on a case-by-case basis and to push for action when necessary.'"

Simonov said his group was collecting complaints and documenting rights abuses about the migrants.

"The most sensitive thing for them is when they don't get paid," he said. "They don't mind the miserable conditions they live in. They're willing to put up with this as long as they get paid."

Up in the mountains in the Krasnaya Polyana area where Ashurov works, 37-year-old Dilya Saipova from Kyrgyzstan was meeting with a potential employer, hoping for a better position than her odd jobs cleaning and working in a kitchen, which she said was strenuous and underpaid.

Local employers "can't pull these things off" with Russians, Saipova said, because "Russians have a law and they can assert their rights using that law."

Workers in Sochi "consistently" spoke about employers failing to pay full wages and in some cases failing to pay workers at all, the HRW report said.

The Olympic venues where workers interviewed by Human Rights Watch reported abuse are the Olympic Stadium, the Olympic Village and the media center in the coastal cluster. Simonov's group is working on a complaint concerning the media center filed by 20 Uzbek workers seeking back wages worth a total of 1 million rubles ($33,000) from a subcontractor.

Dmitry Chernyshenko, head of the Sochi organizing committee, has denied any mistreatment of workers at Olympic sites.

"If there are some violations and people go to prosecutors ? believe me in Russia the law is always on the side of laborers, not on the side of the employer," he said in an interview.

Sochi Mayor Anatoly Pakhomov also dismissed the claims of rights abuses in his city, saying that "conflicts like this are very few."

"If the violations of labor laws were widespread, the online community would be all over it. We don't see anything big in the Internet," he said.

Simonov meets with migrant workers at his one-room office in a dilapidated Sochi neighborhood overlooking the construction site of a new railway terminal. He believes that Sochi authorities and contractors do not realize how important the migrants are to the games.

"At the end of the day, it's only thanks to them that we're getting the Olympic venues built," he said. "No one else will be building them, where would you get so many workers from? Locals don't want these jobs."

Interviewed by Simonov, Ashurov smiles when he is asked if he would like to attend the opening of the 2014 Sochi Games, which run from Feb. 7-23.

"I don't know. I would rather go home and see my family," he said.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-02-06-Sochi-Migrants/id-836c35e0f16c4fa9a67899e35ee8a9d3

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